BiomEdit / Patents and Publications
Peer-reviewed science and protected IP behind our platform
From strain engineering to field performance, our work is published in peer-reviewed scientific journals and covered by a comprehensive intellectual property (IP) strategy.
Peer-reviewed publications from our scientists.
Latest Publication
Low-Dimensional Coexistence in Complex Microbial Ecosystems
This study shows that the complex environmental exposures shaping host-associated microbiome composition can be summarized by variation along just a handful of effective axes, or dimensions, using a joint species distribution model to infer that dimensionality directly from microbial abundance data. This low dimensionality is tied to differences in environmental complexity, competition, diversity, and ecological strategy across microbiomes, and can be explained by correlated variation in resources like dietary nutrients combined with metabolic trade-offs within individual microbial species. The framework also revealed a strong signature of diet complexity and health status, offering a new ecological lens for understanding gut microbiome dysbiosis, and gives a quantitative bridge between statistical-physics models of microbiomes and long-standing niche theory in macroecology.
Read the paper
Recombinant Limosilactobacillus reuteri strains expressing nanobodies against Clostridium perfringens toxins improve broiler performance during subclinical necrotic enteritis challenge
Lactobacillus-vectored nanobodies improve broiler productivity under sub-clinical necrotic enteritis with associated microbiome and transcriptome changes
Interactions between time on diet, antibiotic treatment, and liver abscess development on the fecal microbiome of beef cattle
Designing host-associated microbiomes using the consumer/resource model
Effects of Limosilactobacillus reuteri strains PTA-126787 and PTA-126788 on intestinal barrier integrity and immune homeostasis in an alcohol-induced leaky gut model
Evolving understanding of rumen methanogen ecophysiology
In silico, in vitro and in vivo characterization of host-associated Latilactobacillus curvatus strains for potential probiotic applications in farmed Atlantic salmon (Salmo salar)
Transcriptome Analyses of Chicken Primary Macrophages Infected With Attenuated Salmonella Typhimurium Mutants
Growth promotion and antibiotic induced metabolic shifts in the chicken gut microbiome
Recombinant Limosilactobacillus (Lactobacillus) delivering nanobodies against Clostridium perfringens NetB and alpha toxin confers potential protection from necrotic enteritis
In silico, in vitro and in vivo safety evaluation of Limosilactobacillus reuteri strains ATCC PTA-126787 & ATCC PTA-126788 for potential probiotic applications
Multi-Omics Characterization of Host-Derived Bacillus spp. Probiotics for Improved Growth Performance in Poultry
A selection of patents securing our Programmable Veterinary Biologics™ platform.
BiomEdit has been issued several patents over the past four years, including two recent U.S. patents: “Genetically Modified Lactobacillus and Uses Thereof” (U.S. Patent 12,599,637) and “Probiotic Compositions Comprising Lactobacillus reuteri Strains and Methods of Use” (U.S. Patent 12,427,174). Each establishes protection for engineered Lactobacillus reuteri strains, including composition of matter and methods of use, and systems used to deliver biologically active molecules directly within the host. These patents are part of our Programmable Veterinary Biologics platform.
U.S. Patent 12,599,637
“Genetically Modified Lactobacillus and Uses Thereof”
U.S. Patent 12,427,174
“Probiotic Compositions Comprising Lactobacillus reuteri Strains and Methods of Use”
These two patents cover:
- Engineered Lactobacillus reuteri strains capable of expressing therapeutic biomolecules in situ.
- Delivery systems enabling localized and sustained payload expression.
- Expression of biologically active proteins, including novel antibodies targeting Clostridium perfringens, a significant pathogen in animal health.
- Applications across multiple species, spanning livestock, pets and human health.
